Designer Protein-Based Performance Materials

Protein-Based Drug-Delivery Materials

There is a pressing need for long-term, controlled drug release for sustained treatment of chronic or persistent medical conditions and diseases. Guided drug delivery is difficult because therapeutic compounds need to survive numerous transport barriers and binding targets throughout the body. Nanoscale protein-based polymers are increasingly used for drug and vaccine delivery to cross these bi...

Designer disordered materials with large, complete photonic band gaps.

We present designs of 2D, isotropic, disordered, photonic materials of arbitrary size with complete band gaps blocking all directions and polarizations. The designs with the largest band gaps are obtained by a constrained optimization method that starts from a hyperuniform disordered point pattern, an array of points whose number variance within a spherical sampling window grows more slowly tha...

2D-Based Nanofluids: Materials Evaluation and Performance

Advancement in technology demands the successful utilization of energy and its management in a greater extent. Thermal energy management plays a crucial role from high-payload electrical instruments to ultra-small electronic circuitries. The advent of nanofluids that happened in the 1990s successfully addressed the low thermal efficiency of conventional fluids in a significant manner. The groun...

Designer protein disaggregases to counter neurodegenerative disease.

Protein misfolding and aggregation unify several devastating neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. There are no effective therapeutics for these disorders and none that target the reversal of the aberrant protein misfolding and aggregation that cause disease. Here, I showcase important advances to define, engineer, an...

Design of Protein Cage – Based Biohybrid Materials